This is a support website for the article "Les affinités électives” published in Pour la Science in 2005.

• French published original, ~3.1 MB, PDF format
• English version of the paper, under the original title "Genomic and Non-Genomic Roots of Degeneracy," ~1.1 MB, PDF format
• Formal model (1996): abstract, complete text in PDF (may require a registration), or request a reprint from the author by e-mail
• A similar popular article on degenerate repertoires and references to that paper

© 2004 Sergei Atamas All rights reserved. No part of this material may be copied or reproduced in any form or by any means, without the prior written permission of the author.

The list of references below is by no means exhaustive. The author will appreciate suggestions for additional references to be added to this list.

Degenerate Repertoires - Theory

• Jerne NK. Antibodies and learning: selection versus instruction. In: The Neurosciences. G.C. Quarton, T. Melnechuk, F.O. Schmitt, Eds., The Rockefeller University Press, pp. 200-205, 1967.
• The Mindful Brain: Cortical Organization and the Group-Selective Theory of Higher Brain Function. G. M. Edelmann, V. B. Mountcastle, Eds., MIT Press, 1978.
• Edelman GM, Gally JA. Degeneracy and complexity in biological systems. Proc Natl Acad Sci USA. 2001, 98(24):13763-8. [Abstract]

Protein Binding Degeneracy

• Ma B, Shatsky M, Wolfson HJ, Nussinov R. Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations. Protein Sci. 2002, 11(2):184-97. [Abstract]

Statistical Analysis and Computer Modeling of Degenerate Repertoires

• Rosenwald S, Kafri R, Lancet D. Test of a statistical model for molecular recognition in biological repertoires. J Theor Biol. 2002, 216(3):327-36. [Abstract]
• Lancet D, Sadovsky E, Seidemann E. Probability model for molecular recognition in biological receptor repertoires: significance to the olfactory system. Proc Natl Acad Sci USA. 1993, 90(8):3715-9. [Abstract]
• Chao DL, Davenport MP, Forrest S, Perelson AS. A stochastic model of cytotoxic T cell responses. J Theor Biol. 2004, 228(2):227-40. [Abstract]
• Detours V, Mehr R, Perelson AS. A quantitative theory of affinity-driven T cell repertoire selection. J Theor Biol. 1999, 200(4):389-403. [Abstract]

Stochastic Mechanisms of Gene Expression and Cellular Heterogeneity

• Ozbudak EM, Thattai M, Kurtser I, Grossman AD, van Oudenaarden A. Regulation of noise in the expression of a single gene. Nat Genet. 2002, 31(1):69-73. [Abstract]
• Kupiec JJ. A Darwinian theory for the origin of cellular differentiation. Mol Gen Genet 1997 Jun;255(2):201-8. [Abstract]
• Kupiec JJ. Gene regulation and DNA C-value paradox: a model based on diffusion of regulatory molecules. Med Hypotheses 1989 Jan;28(1):7-10. [Abstract]